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Hereditary tumour test
The Hereditary Tumour Gene Panel includes full sequencing of more than 90 different genes. All of these genes are similar in that they may harbour hereditary mutations which increase your susceptibility to different types of cancer. In addition, the panel includes the examination of more than 300 points in your genome that are related to tumour formation.
Complex genetic screening
Our complex genetic screenings are including tests where we sequence and analyse all scientifically important genes which are playing role in a given disease or syndrome. Mutations in your genes can help you identify which medical screenings should you visit more often. The early identification of health problems are largely increase the possibility of the successful fight against it.
Testing for hereditary breast and ovarian cancer
In the general population, women have a 10% risk of developing breast or ovarian cancer during their life. Breast cancer is the most common malignant tumour in women in Hungary. In about 5-10% of breast cancers, an inherited gene alteration (mutation) is responsible for the disease, while this number is about 12% for ovarian cancer.
If an individual carries a mutation in BRCA1 or BRCA2 genes, she has a 55-88% probability of developing breast cancer until the age of 75 and a 26-48% probability of developing ovarian cancer. The high probability of the development of the diseases justifies the mutation analysis of the BRCA1 and BRCA2 genes in individuals at risk.
Sequencing
Our company covers the whole spectrum of DNA and RNA sequencing. Using our next-generation sequencers, we can chose the most cost-effective solution for a given sample number and the needs of the customer.
Upon request, we undertake capillary sequencing of your samples with our ABI 3500 Genetic Analyzer capillary sequencer.
Testing for cystic fibrosis
Cystic fibrosis (CF, cystic fibrosis, mucoviscidosis) is one of the most prevalent congenital diseases, which is caused by alterations (mutations) in the CFTR (cystic fibrosis transmembrane conductance regulator) gene.
In the Caucasian population one in every 28 persons carries a defective copy of the CFTR gene. Mutation ΔF508del should be highlighted since this deletion is responsible for the clinical aspects of the disease in approximately two-thirds of the patients. If, in a given case, both parents carry a mutation in their CFTR genes they have a 25% probability that their child will be ill. The prevalence of CF justifies the mutational analysis of the CFTR gene.
Testing for lactose intolerance
Lactose, present in milk, is degraded by the lactase enzyme in the small intestine. In lactose intolerance affected people the amount of this enzyme is at its peak during infancy and gradually decreases with age; thus, the ability to degrade lactose also decreases. Based on national data, approximately 35-40% of the Hungarian adult population is sensitive to lactose to some extent.
Testing for predisposition to thrombosis
Venous thrombosis is a multifactorial disease with serious consequences, that is, it is caused by a combination of genetic and environmental factors.
The most important mutations in the affected genes (Leiden, Prothrombin, MTHFR) can be reliably detected with our tests.
Personalized cancer therapy - tumor marker diagnostics
Currently, the most efficient treatment of colorectal and non-small cell lung cancers targets the so called EGFR signalling pathway via its inhibition. To assess the efficiency of targeted therapy, it is essential to analyse the KRAS, NRAS, BRAF and PIK3CA genes, because if these genes contain mutations then the EGFR inhibitor therapy will not affect the tumour cells, but the side effects will remain, further weakening the patient.
Bundled tests and gene panels
With our bundled hereditary tests, you can obtain our tests for a better price than ordering them separately. When creating our offers, we focused on the main genetic alterations found in the European population.